Aerosoltherapy of the upper airway: comparison of  [ Return towards  Scientific information  ]

Passali, Dentici - Italian journal of ORL, Audiology, Phoniatrics

The purpose of this work is to compare a pneumatic atomiser (lower airway nebuliser) and an atomised nasal douche (upper airway nebuliser) in order to identify the more suitable means for treating disorders of the rhinopharynx. Granulometric analysis was performed in advance to calculate the size of the particles delivered by the two nebulisers and the volumes associated with them.
Nasal inhalation of 99mTc-DTPA was performed to scintigraphically highlight the different distribution achieved by the two devices, in the upper and lower airways. The nasal nebuliser appears to limit its action to the rhinopharynx and can therefore be considered more suitable for local treatment.

Is aerosol antibiotic delivery better than oral antibiotic treatment?
Varricchio, Tripodi, et oth.
RF is frequent in children and treatment consists in administering systemic antibiotics that reach the nasal mucosa in a small quantity. Overdosage of antibiotic drugs may also create resistance.
Although it was conducted on a relatively small number of paediatric patients (100 children aged 3-12 years) using a combination of tobramycin, flunisolide and cefaclor inhaled using the Rinowash, this study appears to demonstrate the effectiveness of tobramycin administered by inhalation.